Archive for December, 2008

Molecule shape affects smell perception

December 31, 2008

Molecule shape affects smell perception, says study

By staff reporter, 23-Dec-2008

Changing the shape of the molecules that create fragrances in a flower or fruit may influence our perception of their smell, according to a new study.

In a paper published in the Chemistry & Biology journal a team of researchers led by Dr. Kevin Ryan from The City College of New York set out to investigate how our sensory perception of scent-producing molecules is affected by molecule size.

http://www.cosmeticsdesign.com/Formulation-Science/Molecule-shape-affects-smell-perception-says-study

Call for more research into phthalate health risks

December 21, 2008

Call for more research into phthalate health risks

19-Dec-2008

More research is needed into the health effects of exposure to phthalates from different sources, according to a report from the National Research Council.

Phthalates are found in a wide variety of products including cosmetics, medical devices and building materials, raising concern that widespread exposure poses health risks.

A committee of the independent National Research Council concluded that the US Environmental Protection Agency should carry out more research into cumulative risks.

http://www.cosmeticsdesign.com/Formulation-Science/Call-for-more-research-into-phthalate-health-risks

Industry defends use of antioxidants in skincare

December 21, 2008

By Katie Bird, 18-Dec-2008

Recent research that questioned the potential of antioxidants to fight against aging has elicited a number of reactions from the industry, questioning the relevance of the findings to human skin.

http://www.cosmeticsdesign.com/Formulation-Science/Industry-defends-use-of-antioxidants-in-skincare

Association Questions Formaldehyde Use in Brazilian Straighteners

December 9, 2008

Association Questions Formaldehyde Use in Brazilian Straighteners  Posted: December 2, 2008

The Professional Beauty Association (PBA) has published an advisory to the personal care industry relating to recent media reports questioning the safety of formaldehyde use in Brazilian keratin treatments, known as escova progressiva in Brazil. The PBA alleges that formaldehyde is incorporated in these treatments and that the manufacturers have mislabeled their products, specifically claiming the products are free from formaldehyde.

The PBA notes that experts are concerned with the inhalation of formaldehyde in unsafe quantities, both by salon industry professionals and by consumers. According to the PBA, formaldehyde is commonly used as a preservative in household objects such as glue and particleboard, and that exposure to formaldehyde can be highly irritating, potentially causing severe allergic reactions of the skin, eyes and respiratory tract.

While formaldehyde is a suspected human carcinogen, the Personal Care Product Council’s Cosmetic Ingredient Review (CIR) Expert Panel completed an extensive review of formaldehyde in 1984 and listed it as “safe as used” in cosmetics within certain specifications. These specifications include using it in quantities of less than 2%. CIR also advises, “Formaldehyde should not be used in products intended to be aerosolized.” OSHA does not have a formaldehyde concentration limitation for cosmetic products; however, it is concerned with the concentration of formaldehyde vapors in the atmosphere emanating from products. The OSHA limit is 0.75 ppm over an 8-hr exposure period.

Brazilian straighteners are applied to the hair and heated with a flat iron, vaporizing the formaldehyde and releasing it into the air. According to the PBA, both stylists and clients can be exposed to levels of formaldehyde greater than 0.75 ppm by inhaling these vapors.

Difference Between a Cosmetic and Drug–Warning Letter

December 8, 2008

CFSAN/Office of Cosmetics and Colors:  Warning Letters Address Drug Claims Made for Products Marketed as Cosmetics

The Warning Letters appearing below illustrate an important legal distinction, the difference between a cosmetic and a drug under the Federal Food, Drug, and Cosmetic Act (FD&C Act).

Under the FD&C Act, a product intended to diagnose, mitigate, treat, or prevent disease, or to affect the structure or function of the body is classified as a drug (FD&C Act, Section 201(g)). If such a product is not generally recognized by qualified experts as safe and effective when used as labeled, it is a “new drug” (FD&C Act, Section 201(p)) and requires an approved New Drug Application to be marketed legally in the United States (FD&C Act, Section 505(a)). FDA issued Warning Letters to the following firms citing drug claims associated with topical skin care and hair care preparations, noted on both product labeling and Web sites. Some examples of the drug claims cited are acne treatment, cellulite reduction, stretch mark reduction, wrinkle removal, dandruff treatment, and hair restoration.

Warning Letters Addressing Topical Skin Care Preparations

Warning Letters Addressing Hair Care Preparations

(Comment :  No date listed, but may have come out with or after the FDA release of October 8, 2008 on  Warning Letters Highlight Differences Between Cosmetics and Medical Devices October 8, 2008)

ATSDR –Request for Comments

December 8, 2008

12/2/2008 – ATSDR: Request for Comments on Substances to be Evaluated for Set 23 Toxicological Profiles (PCPC)

The Agency for Toxic Substances and Disease Registry (ATSDR) is requesting comments on a list of 80 priority substances under c
onsideration for inclusion in the set 23 toxicological profiles (Federal Register 73(232): 73329-73332). Substances iin the ATSDR priority list that have INCI names are shown in the table. ATSDR also “invites voluntary public nominations for substances not listed in this notice.” Comments must be submitted by December 24, 2008.

ATSDR Name

INCI Name

CAS No.

chloroform

Chloroform

67-66-3

coal tars

Coal Tar

8007-45-2

di-n-butyl phthalate

Dibuthyl Phthalate

84-74-2

toluene

Toluene

108-88-3

di(2-ethylhexyl)phthalate

Diethylhexyl Phthalate

117-81-7

4-chlorophenol

p-Chlorophenol

106-48-9

palladium

Colloidal Palladium

7440-05-3

acetone

Acetone

67-64-1

butyl benzyl phthalate

Butyl Benzyl Phthalate

85-68-7

2-butanone

MEK

78-93-3

fluoride ion

various compounds such as: Aluminum Fluoride, Ammonium Fluoride, Calcium Fluoride, Sodium Fluoride

16984-48-8

Lack of data makes TTC method inappropriate for cosmetics

December 8, 2008

Lack of data makes TTC method inappropriate for cosmetics   By Katie Bird , 02-Dec-2008

The Threshold for Toxicological Concern (TTC) is not an applicable model for cosmetics ingredients, according to a recent report by three European Committees.   http://www.cosmeticsdesign.com/Formulation-Science/Lack-of-data-makes-TTC-method-inappropriate-for-cosmetics

End of REACH Preregistration: The First Deadline is Here

December 8, 2008

End of REACH Preregistration: The First Deadline is Here   By: Annelie Struessmann, PhD, CONUSBAT  Posted: December 2, 2008

The approach to the new REACH European regulatory framework for chemicals has been documented by this column for more than one year. Looking back to earlier columns, the learning curve was influenced by the publications of the ECHA, and is clearly illustrated by the supportive efforts of the chemical associations, and by companies practically performing the steps required by REACH. The industry has met the end of the preregistration phase now; however, it will not stop meeting new challenges posed by future phases.   http://www.cosmeticsandtoiletries.com/regulatory/reach/35434349.html

Dow Leveraging REACH Registrations

December 8, 2008

Dow Leveraging REACH Registrations   12/03/2008

HORGEN, Switzerland—Dow Chemical Co. established the Dow Only Representative Trustee (ORT) program to leverage its REACH preregistrations and offer cost savings to certain customers. The company noted PricewaterhouseCoopers Advisory N.V. will serve as the DOW ORT, which will allow selected direct non-EU customers and EU importers to use the Dow REACH registrations.

REACH – BASF submits 40,000 preregistrations

December 8, 2008

REACH: BASF submits 40,000 preregistrations   2008-12-02  

The European chemicals policy REACH came into force on June 2007. The first stage is now complete with the end of the preregistration phase on 1 December. BASF submitted some 40,000 preregistrations with the ECHA (European Chemicals Agency) in Helsinki by the deadline, making BASF one of the companies most affected by REACH.   http://www.basf.com/group/pressrelease/P-08-519